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Mechanisms of telomere loss and their consequences for chromosome instability
The ends of chromosomes in mammals, called telomeres, are composed of a 6-bp repeat sequence, TTAGGG, which is added on by the enzyme telomerase. In combination with a protein complex called shelterin, these telomeric repeat sequences form a cap that protects the ends of chromosomes. Due to insuffic...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Frontiers Research Foundation
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3463808/ https://ncbi.nlm.nih.gov/pubmed/23061048 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2012.00135 |
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