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Autophagy and misfolded proteins in neurodegeneration

The accumulation of misfolded proteins in insoluble aggregates within the neuronal cytoplasm is one of the common pathological hallmarks of most adult-onset human neurodegenerative diseases. The clearance of these misfolded proteins may represent a promising therapeutic strategy in these diseases. T...

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Bibliographic Details
Main Authors: Metcalf, Daniel J., García-Arencibia, Moisés, Hochfeld, Warren E., Rubinsztein, David C.
Format: Artigo
Language:Inglês
Published: Academic Press 2012
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3463804/
https://ncbi.nlm.nih.gov/pubmed/21095248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.expneurol.2010.11.003
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