ONCOGENIC BRAF(V600E) PROMOTES STROMAL CELL-MEDIATED IMMUNOSUPPRESSION VIA INDUCTION OF INTERLEUKIN-1 IN MELANOMA

PURPOSE: In this study, we assessed the specific role of BRAF(V600E) signaling in modulating the expression of immune regulatory genes in melanoma, in addition to analyzing downstream induction of immune suppression by primary human melanoma tumor-associated fibroblasts (TAFs). EXPERIMENTAL DESIGN:...

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Hoofdauteurs: Khalili, Jahan S., Liu, Shujuan, Rodríguez-Cruz, Tania G., Whittington, Mayra, Wardell, Seth, Liu, Chengwen, Zhang, Minying, Cooper, Zachary A., Frederick, Dennie T., Li, Yufeng, Zhang, Min, Joseph, Richard W., Bernatchez, Chantale, Ekmekcioglu, Suhendan, Grimm, Elizabeth, Radvanyi, Laszlo G., Davis, Richard E., Davies, Michael A., Wargo, Jennifer A., Hwu, Patrick, Lizée, Gregory
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2012
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3463754/
https://ncbi.nlm.nih.gov/pubmed/22850568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-12-1632
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