Therapeutic Administration of the Direct Thrombin Inhibitor Argatroban Reduces Hepatic Inflammation in Mice with Established Fatty Liver Disease

Thrombin generation is increased in patients with nonalcoholic fatty liver disease (NAFLD) and in mouse models of diet-induced obesity. Deficiency in the thrombin receptor protease activated receptor-1 reduces hepatic inflammation and steatosis in mice fed a Western diet. However, it is currently un...

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Главные авторы: Kassel, Karen M., Sullivan, Bradley P., Cui, Wei, Copple, Bryan L., Luyendyk, James P.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Investigative Pathology 2012
Предметы:
Regular Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3463624/
https://ncbi.nlm.nih.gov/pubmed/22841818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2012.06.011
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