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Chronic Cladribine Administration Increases Amyloid Beta Peptide Generation and Plaque Burden in Mice
BACKGROUND: The clinical uses of 2-chloro-2′-deoxyadenosine (2-CDA) or cladribine which was initially prescribed to patients with hematological and lymphoid cancers is now extended to treat patients with multiple sclerosis (MS). Previous data has shown that 2-CDA has high affinity to the brain and r...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3463612/ https://ncbi.nlm.nih.gov/pubmed/23056220 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0045841 |
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