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Structure Based Design of Novel Pyrimido[4,5-c]pyridazine Derivatives as Dihydropteroate Synthase (DHPS) Inhibitors with Increased Affinity
Dihydropteroate synthase (DHPS) is the validated drug target for sulfonamide antimicrobial therapy. However, due to widespread drug resistance and poor tolerance, the use of the sulfonamide antibiotics is now limited. The pterin binding pocket in DHPS has a high degree of conservation and is distinc...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2012
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3463507/ https://ncbi.nlm.nih.gov/pubmed/22416048 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201200049 |
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