Normalization of sphingomyelin levels by 2-hydroxyoleic acid induces autophagic cell death of SF767 cancer cells

The very high mortality rate of gliomas reflects the unmet therapeutic need associated with this type of brain tumor. We have discovered that the plasma membrane fulfills a critical role in the propagation of tumorigenic signals, whereby changes in membrane lipid content can either activate or silen...

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Main Authors: Terés, Silvia, Lladó, Victoria, Higuera, Mónica, Barceló-Coblijn, Gwendolyn, Martin, M. Laura, Noguera-Salvà, Maria Antònia, Marcilla-Etxenike, Amaia, García-Verdugo, José Manuel, Soriano-Navarro, Mario, Saus, Carlos, Gómez-Pinedo, Ulises, Busquets, Xavier, Escribá, Pablo V.
Format: Artigo
Sprog:Inglês
Udgivet: Landes Bioscience 2012
Fag:
Autophagic Punctum
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3463457/
https://ncbi.nlm.nih.gov/pubmed/22892762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/auto.21341
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