Sphingomyelin and sphingomyelin synthase (SMS) in the malignant transformation of glioma cells and in 2-hydroxyoleic acid therapy

The mechanism of action of 2-hydroxyoleic acid (2OHOA), a potent antitumor compound, has not yet been fully elucidated. Here, we show that human cancer cells have markedly lower levels of sphingomyelin (SM) than nontumor (MRC-5) cells. In this context, 2OHOA treatment strongly augments SM mass (4.6-...

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Detalles Bibliográficos
Main Authors: Barceló-Coblijn, Gwendolyn, Martin, Maria Laura, de Almeida, Rodrigo F. M., Noguera-Salvà, Maria Antònia, Marcilla-Etxenike, Amaia, Guardiola-Serrano, Francisca, Lüth, Anja, Kleuser, Burhard, Halver, John E., Escribá, Pablo V.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2011
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3241787/
https://ncbi.nlm.nih.gov/pubmed/22106271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1115484108
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