The R-Ras/RIN2/Rab5 complex controls endothelial cell adhesion and morphogenesis via active integrin endocytosis and Rac signaling

During developmental and tumor angiogenesis, semaphorins regulate blood vessel navigation by signaling through plexin receptors that inhibit the R-Ras subfamily of small GTPases. R-Ras is mainly expressed in vascular cells, where it induces adhesion to the extracellular matrix (ECM) through unknown...

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Autors principals: Sandri, Chiara, Caccavari, Francesca, Valdembri, Donatella, Camillo, Chiara, Veltel, Stefan, Santambrogio, Martina, Lanzetti, Letizia, Bussolino, Federico, Ivaska, Johanna, Serini, Guido
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2012
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3463263/
https://ncbi.nlm.nih.gov/pubmed/22825554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2012.110
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