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Frequency of UV-induced neoplastic transformation of diploid human fibroblasts is higher in xeroderma pigmentosum cells than in normal cells.

If neoplastic transformation of diploid human cells results from carcinogen-induced mutations, cells deficient in excision repair of UV-induced DNA damage should be significantly more sensitive to transformation by UV light than normal cells. We tested this hypothesis by irradiating fibroblasts from...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Maher, V M, Rowan, L A, Silinskas, K C, Kateley, S A, McCormick, J J
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1982
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC346250/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6953417/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.79.8.2613
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