Inflammatory Signals Enhance Piezo2-Mediated Mechanosensitive Currents

Heightened nociceptor function caused by inflammatory mediators such as bradykinin contributes to increased pain perception (hyperalgesia) to noxious mechanical and thermal stimuli. While sensitization of the heat transducer TRPV1 largely subserves thermal hyperalgesia, cellular mechanisms underlyin...

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Autores principales: Dubin, Adrienne E., Schmidt, Manuela, Mathur, Jayanti, Petrus, Matthew J., Xiao, Bailong, Coste, Bertrand, Patapoutian, Ardem
Formato: Artigo
Lenguaje:Inglês
Publicado: 2012
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3462303/
https://ncbi.nlm.nih.gov/pubmed/22921401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2012.07.014
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