FOXO1 orchestrates the bone-suppressing function of gut-derived serotonin

Serotonin is a critical regulator of bone mass, fulfilling different functions depending on its site of synthesis. Brain-derived serotonin promotes osteoblast proliferation, whereas duodenal-derived serotonin suppresses it. To understand the molecular mechanisms of duodenal-derived serotonin action...

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Bibliographic Details
Main Authors: Kode, Aruna, Mosialou, Ioanna, Silva, Barbara C., Rached, Marie-Therese, Zhou, Bin, Wang, Ji, Townes, Tim M., Hen, Rene, DePinho, Ronald A., Guo, X. Edward, Kousteni, Stavroula
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3461930/
https://ncbi.nlm.nih.gov/pubmed/22945629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI64906
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