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Molecular pathogenesis of multiple myeloma and its premalignant precursor

Multiple myeloma is a monoclonal tumor of plasma cells, and its development is preceded by a premalignant tumor with which it shares genetic abnormalities, including universal dysregulation of the cyclin D/retinoblastoma (cyclin D/RB) pathway. A complex interaction with the BM microenvironment, char...

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Bibliografiske detaljer
Main Authors: Kuehl, W. Michael, Bergsagel, P. Leif
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3461901/
https://ncbi.nlm.nih.gov/pubmed/23023717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI61188
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