Inhibition of p38-MAPK alters SRC coactivation and estrogen receptor phosphorylation

The p38 mitogen activated protein kinase pathway (MAPK) is known to promote cell survival, endocrine therapy resistance and hormone independent breast cancer cell proliferation. Therefore, we utilized the novel p38 inhibitor RWJ67657 to investigate the relevance of targeting this pathway in the ER(+...

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Hlavní autoři: Antoon, James W., Bratton, Melyssa R., Guillot, Lori M., Wadsworth, Scott, Salvo, Virgilio A., Burow, Matthew E.
Médium: Artigo
Jazyk:Inglês
Vydáno: Landes Bioscience 2012
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3461809/
https://ncbi.nlm.nih.gov/pubmed/22825349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.20992
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