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Application of a Trifunctional Reactive Linker for the Construction of Antibody-Drug Hybrid Conjugates
A flexible, trifunctional poly(ethylene glycol)-succinamide-Lysine-Lysine-maleimide (PEG-SU-Lys-Lys-mal) linker was employed to simultaneously allow biotin tagging and cell-surface targeting through an integrin α(4)β(1)-binding peptidomimetic that was regiospecifically conjugated to an IgG1-derived...
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| Autores principales: | , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2008
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3461582/ https://ncbi.nlm.nih.gov/pubmed/18922692 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2008.09.078 |
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