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Lovastatin Induces Multiple Stress Pathways Including LKB1/AMPK Activation That Regulate Its Cytotoxic Effects in Squamous Cell Carcinoma Cells

BACKGROUND: Cellular stress responses trigger signaling cascades that inhibit proliferation and protein translation to help alleviate the stress or if the stress cannot be overcome induce apoptosis. In recent studies, we demonstrated the ability of lovastatin, an inhibitor of mevalonate synthesis, t...

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Bibliografische gegevens
Hoofdauteurs: Ma, Laurie, Niknejad, Nima, Gorn-Hondermann, Ivan, Dayekh, Khalil, Dimitroulakos, Jim
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2012
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3460930/
https://ncbi.nlm.nih.gov/pubmed/23029387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0046055
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