Lovastatin Induces Multiple Stress Pathways Including LKB1/AMPK Activation That Regulate Its Cytotoxic Effects in Squamous Cell Carcinoma Cells

BACKGROUND: Cellular stress responses trigger signaling cascades that inhibit proliferation and protein translation to help alleviate the stress or if the stress cannot be overcome induce apoptosis. In recent studies, we demonstrated the ability of lovastatin, an inhibitor of mevalonate synthesis, t...

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Hauptverfasser: Ma, Laurie, Niknejad, Nima, Gorn-Hondermann, Ivan, Dayekh, Khalil, Dimitroulakos, Jim
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2012
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3460930/
https://ncbi.nlm.nih.gov/pubmed/23029387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0046055
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