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3-Methyladenine: Specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes

3-Methyladenine (5 mM) inhibits endogenous protein degradation in isolated rat hepatocytes by about 60%, while having no adverse effect on the degradation of an exogenous protein (asialofetuin), on protein synthesis, or on intracellular ATP levels. 3-Methyladenine appears to act specifically upon th...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Proc Natl Acad Sci U S A
Prif Awduron: Seglen, Per O., Gordon, Paul B.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 1982
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC346086/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6952238/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.79.6.1889
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