Toosendanin Induces Hepatocyte Damage by Inhibiting Autophagic Flux via TFEB-Mediated Lysosomal Dysfunction
Toosendanin (TSN) is a triterpenoid from the fruit or bark of <i>Melia toosendan</i> Sieb et Zucc, which has clear antitumor and insecticidal activities, but it possesses limiting hepatotoxicity in clinical application. Autophagy is a degradation and recycling mechanism to maintain cellular homeosta...
Gorde:
| Egile Nagusiak: | , , , , , , , |
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| Formatua: | Artigo |
| Hizkuntza: | Inglês |
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MDPI AG
2022-12-01
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| Saila: | Pharmaceuticals |
| Gaiak: | |
| Sarrera elektronikoa: | https://www.mdpi.com/1424-8247/15/12/1509 |
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