TFEB overexpression alleviates autophagy-lysosomal deficits caused by progranulin insufficiency

Abstract Progranulin is a pro-protein that is necessary for maintaining lysosomal function. Loss-of-function progranulin (GRN) mutations are a dominant cause of frontotemporal dementia (FTD). Brains of people with FTD due to GRN mutations accumulate lysosomal storage material and exhibit increased e...

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Autori principali:	Wren O. Nader, Kaylan S. Brown, Nicholas R. Boyle, Azariah K. Kaplelach, Shaimaa M. Abdelaziz, Skylar E. Davis, Qays Aljabi, Ahmad R. Hakim, Amelia G. Davidson, Giacynta A. Vollmer, Leah C. Wright, J. Bailey Echols, Joelle Saad, Nicholas S. Pena, Andrew E. Arrant
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Portfolio 2025-07-01
Serie:	Scientific Reports
Soggetti:	Progranulin TFEB Lysosomes Autophagy
Accesso online:	https://doi.org/10.1038/s41598-025-12268-0
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