Human TDP-43 expression worsens FTD-related phenotypes in progranulin-insufficient mice

Loss-of-function progranulin (GRN) mutations cause frontotemporal dementia with TDP-43 pathology (FTD-TDP). Nearly all pathogenic GRN mutations cause progranulin haploinsufficiency, but it is unclear how progranulin insufficiency causes FTD-TDP. To address this question, we crossed progranulin-insuf...

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Autors principals:	Anna K. Cook, Benjamin Lin, Yumo Song, Kelsey M. Greathouse, Azariah K. Kaplelach, Mackenzie L. Love, Skylar E. Davis, Anna C. Stoll, Justin A. Hall, Ahmad R. Hakim, Jakub F. Hel, Giacynta A. Vollmer, Alexandria C. Howard, Noelle H. Cooper, Phaedra N. Manuel, Juliana M. Eberhardt, C. Ryan Miller, Ashley S. Harms, Jeremy H. Herskowitz, Lindsay F. Rizzardi, Andrew E. Arrant
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2026-09-01
Col·lecció:	Neurobiology of Disease
Matèries:	TDP-43 Progranulin Frontotemporal dementia
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S0969996126002202
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