Human TDP-43 expression worsens FTD-related phenotypes in progranulin-insufficient mice

Loss-of-function progranulin (GRN) mutations cause frontotemporal dementia with TDP-43 pathology (FTD-TDP). Nearly all pathogenic GRN mutations cause progranulin haploinsufficiency, but it is unclear how progranulin insufficiency causes FTD-TDP. To address this question, we crossed progranulin-insuf...

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मुख्य लेखकों:	Anna K. Cook, Benjamin Lin, Yumo Song, Kelsey M. Greathouse, Azariah K. Kaplelach, Mackenzie L. Love, Skylar E. Davis, Anna C. Stoll, Justin A. Hall, Ahmad R. Hakim, Jakub F. Hel, Giacynta A. Vollmer, Alexandria C. Howard, Noelle H. Cooper, Phaedra N. Manuel, Juliana M. Eberhardt, C. Ryan Miller, Ashley S. Harms, Jeremy H. Herskowitz, Lindsay F. Rizzardi, Andrew E. Arrant
स्वरूप:	Artigo
भाषा:	Inglês
प्रकाशित:	Elsevier 2026-09-01
श्रृंखला:	Neurobiology of Disease
विषय:	TDP-43 Progranulin Frontotemporal dementia
ऑनलाइन पहुंच:	http://www.sciencedirect.com/science/article/pii/S0969996126002202
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