Failure of lysosomal acidification and endomembrane network in neurodegeneration
Abstract Lysosomes have emerged as central hubs in the regulation of the endomembrane system, extending beyond degradation to coordinate organelle communication. Central to this regulatory role is vacuolar-type H+-ATPase (V-ATPase), a proton pump that acidifies the lysosomal lumen to enable hydrolas...
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| Autors principals: | , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group
2025-11-01
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| Col·lecció: | Experimental and Molecular Medicine |
| Accés en línia: | https://doi.org/10.1038/s12276-025-01579-x |
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