LAPF enhances lysosomal acidification to promote TLR9 and cGAS-STING-mediated antiviral immunity and attenuate HSV-1-induced neuroinflammatory pain

Abstract Postherpetic neuralgia (PHN) is characterized by neural injury and neuroinflammation resulting from viral infection and reactivation. Herpes simplex virus type 1 (HSV-1) is capable of inducing virus-associated PHN-like neuropathic pain and has been widely used as a model for studying virus-...

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Autores principales:	Erliang Kong, Mengqiu Deng, Ruifeng Ding, Mei Yang, Yongchang Li, Xudong Feng, Honghao Song, Huawei Wei, Xin Jiang, Hongbin Yuan, Chaofeng Han
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	BMC 2026-05-01
Colección:	Journal of Neuroinflammation
Materias:	Postherpetic neuralgia Neuroinflammation Antiviral innate immunity Lysosomal acidification Lysosomal membrane stability LAPF
Acceso en línea:	https://doi.org/10.1186/s12974-026-03856-6
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