RORα Induces KLF4-Mediated M2 Polarization in the Liver Macrophages that Protect against Nonalcoholic Steatohepatitis

The regulation of M1/M2 polarization in liver macrophages is closely associated with the progression of nonalcoholic steatohepatitis (NASH); however, the mechanism involved in this process remains unclear. Here, we describe the orphan nuclear receptor retinoic-acid-related orphan receptor α (RORα) a...

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Hlavní autoři:	Yong-Hyun Han, Hyeon-Ji Kim, Hyelin Na, Min-Woo Nam, Ju-Yeon Kim, Jun-Seok Kim, Seung-Hoi Koo, Mi-Ock Lee
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Elsevier 2017-07-01
Edice:	Cell Reports
Témata:	RORα Kupffer cells M2 polarity KLF4 non-alcoholic steatohepatitis
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S2211124717308148
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