A GxxxG-like Motif within HIV-1 Fusion Peptide Is Critical to Its Immunosuppressant Activity, Structure, and Interaction with the Transmembrane Domain of the T-cell Receptor

To thrive in the human body, HIV fuses to its target cell and evades the immune response via several mechanisms. The fusion cascade is initiated by the fusion peptide (FP), which is located at the N-terminal of gp41, the transmembrane protein of HIV. Recently, it has been shown that the HIV-1 FP, pa...

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Bibliographic Details
Main Authors: Faingold, Omri, Cohen, Tomer, Shai, Yechiel
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2012
Subjects:
Molecular Biophysics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3460451/
https://ncbi.nlm.nih.gov/pubmed/22872636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.370817
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