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Copy number variation leads to considerable diversity for B but not A haplotypes of the human KIR genes encoding NK cell receptors

The KIR complex appears to be evolving rapidly in humans, and more than 50 different haplotypes have been described, ranging from four to 14 KIR loci. Previously it has been suggested that most KIR haplotypes consist of framework genes, present in all individuals, which bracket a variable number of...

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Détails bibliographiques
Auteurs principaux: Jiang, Wei, Johnson, Chris, Jayaraman, Jyothi, Simecek, Nikol, Noble, Janelle, Moffatt, Miriam F., Cookson, William O., Trowsdale, John, Traherne, James A.
Format: Artigo
Langue:Inglês
Publié: Cold Spring Harbor Laboratory Press 2012
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3460180/
https://ncbi.nlm.nih.gov/pubmed/22948769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.137976.112
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