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Abnormal developmental control of replication-timing domains in pediatric acute lymphoblastic leukemia

Abnormal replication timing has been observed in cancer but no study has comprehensively evaluated this misregulation. We generated genome-wide replication-timing profiles for pediatric leukemias from 17 patients and three cell lines, as well as normal B and T cells. Nonleukemic EBV-transformed lymp...

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Main Authors: Ryba, Tyrone, Battaglia, Dana, Chang, Bill H., Shirley, James W., Buckley, Quinton, Pope, Benjamin D., Devidas, Meenakshi, Druker, Brian J., Gilbert, David M.
格式: Artigo
語言:Inglês
出版: Cold Spring Harbor Laboratory Press 2012
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3460179/
https://ncbi.nlm.nih.gov/pubmed/22628462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.138511.112
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