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Cyclic AMP/PKA-dependent paradoxical activation of Raf/MEK/ERK signaling in polycystin-2 defective mice treated with Sorafenib
Mutations in polycystins (PC1 or PC2) are a cause of polycystic liver disease (PLD-ADPKD). In PC2-defective mice, cAMP/PKA-dependent activation of the Ras/Raf/MEK-ERK1/2 pathway stimulates the growth of liver cysts. To test the hypothesis that sorafenib, a Raf-inhibitor used for the treatment of liv...
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| 主要な著者: | , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2012
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3460040/ https://ncbi.nlm.nih.gov/pubmed/22653837 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.25872 |
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