Cyclic AMP/PKA-dependent paradoxical activation of Raf/MEK/ERK signaling in polycystin-2 defective mice treated with Sorafenib

Mutations in polycystins (PC1 or PC2) are a cause of polycystic liver disease (PLD-ADPKD). In PC2-defective mice, cAMP/PKA-dependent activation of the Ras/Raf/MEK-ERK1/2 pathway stimulates the growth of liver cysts. To test the hypothesis that sorafenib, a Raf-inhibitor used for the treatment of liv...

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Hauptverfasser: Spirli, Carlo, Morell, Carola M., Locatelli, Luigi, Okolicsanyi, Stefano, Ferrero, Cecilia, Kim, Amy K., Fabris, Luca, Fiorotto, Romina, Strazzabosco, Mario
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3460040/
https://ncbi.nlm.nih.gov/pubmed/22653837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.25872
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