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Developing treatment for spinal and bulbar muscular atrophy
Spinal and bulbar muscular atrophy is unique among the polyglutamine diseases in that the toxicity of the mutant protein, the androgen receptor, is ligand-dependent. In cell culture and animal models the mutant androgen receptor causes protein aggregation and alterations in transcriptional regulatio...
Bewaard in:
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2012
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3460036/ https://ncbi.nlm.nih.gov/pubmed/22668795 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pneurobio.2012.05.012 |
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