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Therapeutic approaches to spinal and bulbar muscular atrophy
Spinal and bulbar muscular atrophy is a hereditary motor neuron disease caused by trinucleotide repeat expansion in the androgen receptor gene. The disease mechanism probably involves a toxic gain of function in the mutant protein, because other mutations that cause a loss of androgen receptor funct...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2963653/ https://ncbi.nlm.nih.gov/pubmed/20863580 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tips.2010.08.005 |
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