MGMT Inhibition Restores ERα Functional Sensitivity to Antiestrogen Therapy

Antiestrogen therapy resistance remains a huge stumbling block in the treatment of breast cancer. We have found significant elevation of O(6) methylguanine DNA methyl transferase (MGMT) expression in a small sample of consecutive patients who have failed tamoxifen treatment. Here, we show that tamox...

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Bibliographische Detailangaben
Hauptverfasser: Bobustuc, George C, Smith, Joshua S, Maddipatla, Sreeram, Jeudy, Sheila, Limaye, Arati, Isley, Beth, Caparas, Maria-Lourdes M, Constantino, Susan M, Shah, Nikita, Baker, Cheryl H, Srivenugopal, Kalkunte S, Baidas, Said, Konduri, Santhi D
Format: Artigo
Sprache:Inglês
Veröffentlicht: ScholarOne 2012
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3459485/
https://ncbi.nlm.nih.gov/pubmed/22549111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2119/molmed.2012.00010
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