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Tetraploid State Induces p53-dependent Arrest of Nontransformed Mammalian Cells in G1

A “spindle assembly” checkpoint has been described that arrests cells in G1 following inappropriate exit from mitosis in the presence of microtubule inhibitors. We have here addressed the question of whether the resulting tetraploid state itself, rather than failure of spindle function or induction...

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Détails bibliographiques
Auteurs principaux: Andreassen, Paul R., Lohez, Olivier D., Lacroix, Françoise B., Margolis, Robert L.
Format: Artigo
Langue:Inglês
Publié: The American Society for Cell Biology 2001
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC34586/
https://ncbi.nlm.nih.gov/pubmed/11359924
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