Tetraploid State Induces p53-dependent Arrest of Nontransformed Mammalian Cells in G1

Eitemau Tebyg

• Arrest of mammalian fibroblasts in G1 in response to actin inhibition is dependent on retinoblastoma pocket proteins but not on p53
  gan: Lohez, Olivier D., et al.
  Cyhoeddwyd: (2003)
• Multiple centrosomes arise from tetraploidy checkpoint failure and mitotic centrosome clusters in p53 and RB pocket protein-compromised cells
  gan: Borel, Franck, et al.
  Cyhoeddwyd: (2002)
• p53 and DNA-dependent protein kinase catalytic subunit independently function in regulating actin damage-induced tetraploid G1 arrest
  gan: Chae, Hee-Don, et al.
  Cyhoeddwyd: (2012)
• Multiple kinase arrest points in the G1 phase of nontransformed mammalian cells are absent in transformed cells.
  gan: Gadbois, D M, et al.
  Cyhoeddwyd: (1992)
• Overexpression of MYC causes p53-dependent G(2) arrest of normal fibroblasts
  gan: Felsher, Dean W., et al.
  Cyhoeddwyd: (2000)