p21 promotes error-free replication-coupled DNA double-strand break repair

p21 is a well-established regulator of cell cycle progression. The role of p21 in DNA repair, however, remains poorly characterized. Here, we describe a critical role of p21 in a replication-coupled DNA double-strand break (DSB) repair that is mechanistically distinct from its cell cycle checkpoint...

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Bibliographic Details
Main Authors: Mauro, Maurizio, Rego, Meghan A., Boisvert, Rebecca A., Esashi, Fumiko, Cavallo, Francesca, Jasin, Maria, Howlett, Niall G.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2012
Subjects:
Genome Integrity, Repair and Replication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3458556/
https://ncbi.nlm.nih.gov/pubmed/22735704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks612
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