Terminal deoxynucleotidyl transferase requires KU80 and XRCC4 to promote N-addition at non-V(D)J chromosomal breaks in non-lymphoid cells

Terminal deoxynucleotidyl transferase (TdT) is a DNA polymerase that increases the repertoire of antigen receptors by adding non-templated nucleotides (N-addition) to V(D)J recombination junctions. Despite extensive in vitro studies on TdT catalytic activity, the partners of TdT that enable N-additi...

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Main Authors: Boubakour-Azzouz, Imenne, Bertrand, Pascale, Claes, Aurélie, Lopez, Bernard S., Rougeon, François
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2012
Teme:
Genome Integrity, Repair and Replication
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3458542/
https://ncbi.nlm.nih.gov/pubmed/22740656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks585
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