Ku80 is required for addition of N nucleotides to V(D)J recombination junctions by terminal deoxynucleotidyl transferase

V(D)J recombination generates a remarkably diverse repertoire of antigen receptors through the rearrangement of germline DNA. Terminal deoxynucleotidyl transferase (TdT), a polymerase that adds random nucleotides (N regions) to recombination junctions, is a key enzyme contributing to this diversity....

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Hlavní autoři: Purugganan, Mary M., Shah, Sundeep, Kearney, John F., Roth, David B.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2001
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC31272/
https://ncbi.nlm.nih.gov/pubmed/11266568
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