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Tuberin Inhibits Production of the Matrix Protein Fibronectin in Diabetes

Exposure of proximal tubular epithelial cells to high glucose contributes to the accumulation of tubulointerstitial and matrix proteins in diabetic nephropathy, but how this occurs is not well understood. We investigated the effect of the signaling molecule tuberin, which modulates the mammalian tar...

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Détails bibliographiques
Auteurs principaux: Habib, Samy L., Yadav, Mukesh, Tizani, Shaza, Bhandari, Basant, Valente, Anthony J.
Format: Artigo
Langue:Inglês
Publié: American Society of Nephrology 2012
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3458468/
https://ncbi.nlm.nih.gov/pubmed/22904348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2012030285
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