Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors

The presence of growth-induced solid stresses in tumors has been suspected for some time, but these stresses were largely estimated using mathematical models. Solid stresses can deform the surrounding tissues and compress intratumoral lymphatic and blood vessels. Compression of lymphatic vessels ele...

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Main Authors: Stylianopoulos, Triantafyllos, Martin, John D., Chauhan, Vikash P., Jain, Saloni R., Diop-Frimpong, Benjamin, Bardeesy, Nabeel, Smith, Barbara L., Ferrone, Cristina R., Hornicek, Francis J., Boucher, Yves, Munn, Lance L., Jain, Rakesh K.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2012
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3458380/
https://ncbi.nlm.nih.gov/pubmed/22932871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1213353109
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