Ras and GTPase-activating protein (GAP) drive GTP into a precatalytic state as revealed by combining FTIR and biomolecular simulations

Members of the Ras superfamily regulate many cellular processes. They are down-regulated by a GTPase reaction in which GTP is cleaved into GDP and P(i) by nucleophilic attack of a water molecule. Ras proteins accelerate GTP hydrolysis by a factor of 10(5) compared to GTP in water. GTPase-activating...

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Detaylı Bibliyografya
Asıl Yazarlar: Rudack, Till, Xia, Fei, Schlitter, Jürgen, Kötting, Carsten, Gerwert, Klaus
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2012
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3458370/
https://ncbi.nlm.nih.gov/pubmed/22949691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1204333109
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