Catalysis of GTP Hydrolysis by Small GTPases at Atomic Detail by Integration of X-ray Crystallography, Experimental, and Theoretical IR Spectroscopy

Small GTPases regulate key processes in cells. Malfunction of their GTPase reaction by mutations is involved in severe diseases. Here, we compare the GTPase reaction of the slower hydrolyzing GTPase Ran with Ras. By combination of time-resolved FTIR difference spectroscopy and QM/MM simulations we e...

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Опубликовано в: :J Biol Chem
Главные авторы: Rudack, Till, Jenrich, Sarah, Brucker, Sven, Vetter, Ingrid R., Gerwert, Klaus, Kötting, Carsten
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2015
Предметы:
Molecular Biophysics
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4591799/
https://ncbi.nlm.nih.gov/pubmed/26272610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.648071
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