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Catalytic mechanism of a mammalian Rab·RabGAP complex in atomic detail
Rab GTPases, key regulators of vesicular transport, hydrolyze GTP very slowly unless assisted by Rab GTPase-activating proteins (RabGAPs). Dysfunction of RabGAPs is involved in many diseases. By combining X-ray structure analysis and time-resolved FTIR spectroscopy we reveal here the detailed molecu...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3535612/ https://ncbi.nlm.nih.gov/pubmed/23236136 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1214431110 |
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