UTX regulates mesoderm differentiation of embryonic stem cells independent of H3K27 demethylase activity

To investigate the role of histone H3K27 demethylase UTX in embryonic stem (ES) cell differentiation, we have generated UTX knockout (KO) and enzyme-dead knock-in male ES cells. Deletion of the X-chromosome-encoded UTX gene in male ES cells markedly decreases expression of the paralogous UTY gene en...

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Main Authors: Wang, Chaochen, Lee, Ji-Eun, Cho, Young-Wook, Xiao, Ying, Jin, Qihuang, Liu, Chengyu, Ge, Kai
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2012
主題:
Biological Sciences
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3458330/
https://ncbi.nlm.nih.gov/pubmed/22949634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1204166109
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