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UTX regulates mesoderm differentiation of embryonic stem cells independent of H3K27 demethylase activity
To investigate the role of histone H3K27 demethylase UTX in embryonic stem (ES) cell differentiation, we have generated UTX knockout (KO) and enzyme-dead knock-in male ES cells. Deletion of the X-chromosome-encoded UTX gene in male ES cells markedly decreases expression of the paralogous UTY gene en...
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| Autori principali: | , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3458330/ https://ncbi.nlm.nih.gov/pubmed/22949634 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1204166109 |
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