UTX and UTY Demonstrate Histone Demethylase-Independent Function in Mouse Embryonic Development

UTX (KDM6A) and UTY are homologous X and Y chromosome members of the Histone H3 Lysine 27 (H3K27) demethylase gene family. UTX can demethylate H3K27; however, in vitro assays suggest that human UTY has lost enzymatic activity due to sequence divergence. We produced mouse mutations in both Utx and Ut...

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Detaylı Bibliyografya
Asıl Yazarlar: Shpargel, Karl B., Sengoku, Toru, Yokoyama, Shigeyuki, Magnuson, Terry
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2012
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3459986/
https://ncbi.nlm.nih.gov/pubmed/23028370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1002964
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