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UTX and UTY Demonstrate Histone Demethylase-Independent Function in Mouse Embryonic Development
UTX (KDM6A) and UTY are homologous X and Y chromosome members of the Histone H3 Lysine 27 (H3K27) demethylase gene family. UTX can demethylate H3K27; however, in vitro assays suggest that human UTY has lost enzymatic activity due to sequence divergence. We produced mouse mutations in both Utx and Ut...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Public Library of Science
2012
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3459986/ https://ncbi.nlm.nih.gov/pubmed/23028370 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1002964 |
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