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Structural basis for histone H3 Lys 27 demethylation by UTX/KDM6A
Tri- and dimethylations of histone H3K9 (H3K9me3/2) and H3K27 (H3K27me3/2), both situated in the “A-R-Kme-S” sequence motif, mediate transcriptional repression of distinct genomic regions. H3K9me3/2 mainly governs constitutive heterochromatin formation, while H3K27me3/2 represses key developmental g...
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| Auteurs principaux: | , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Cold Spring Harbor Laboratory Press
2011
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3219231/ https://ncbi.nlm.nih.gov/pubmed/22002947 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.172296.111 |
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