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KDM7 is a dual demethylase for histone H3 Lys 9 and Lys 27 and functions in brain development

Methylation of histone H3 Lys 9 and Lys 27 (H3K9 and H3K27) is associated with transcriptional silencing. Here we show that KDM7, a JmjC domain-containing protein, catalyzes demethylation of both mono- or dimethylated H3K9 and H3K27. Inhibition of KDM7 orthologs in zebrafish resulted in developmenta...

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Detalhes bibliográficos
Main Authors: Tsukada, Yu-ichi, Ishitani, Tohru, Nakayama, Keiichi I.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2827838/
https://ncbi.nlm.nih.gov/pubmed/20194436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1864410
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