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KDM7 is a dual demethylase for histone H3 Lys 9 and Lys 27 and functions in brain development
Methylation of histone H3 Lys 9 and Lys 27 (H3K9 and H3K27) is associated with transcriptional silencing. Here we show that KDM7, a JmjC domain-containing protein, catalyzes demethylation of both mono- or dimethylated H3K9 and H3K27. Inhibition of KDM7 orthologs in zebrafish resulted in developmenta...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Cold Spring Harbor Laboratory Press
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2827838/ https://ncbi.nlm.nih.gov/pubmed/20194436 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1864410 |
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