T follicular helper cell-dependent clearance of a persistent virus infection requires T cell expression of the histone demethylase UTX

Epigenetic changes, including histone methylation, control T cell differentiation and memory formation, though the enzymes that mediate these processes are not clear. We show that UTX, a histone H3 lysine 27 (H3K27) demethylase, supports T follicular helper (Tfh) cell responses that are essential fo...

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Publicado en:Immunity
Autores principales: Cook, Kevin D., Shpargel, Karl B., Starmer, Joshua, Whitfield-Larry, Fatima, Conley, Bridget, Allard, Denise E., Rager, Julia E., Fry, Rebecca C., Davenport, Marsha L., Magnuson, Terry, Whitmire, Jason K., Su, Maureen A.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4731234/
https://ncbi.nlm.nih.gov/pubmed/26431949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2015.09.002
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