Paralogous ALT1 and ALT2 Retention and Diversification Have Generated Catalytically Active and Inactive Aminotransferases in Saccharomyces cerevisiae

BACKGROUND: Gene duplication and the subsequent divergence of paralogous pairs play a central role in the evolution of novel gene functions. S. cerevisiae possesses two paralogous genes (ALT1/ALT2) which presumably encode alanine aminotransferases. It has been previously shown that Alt1 encodes an a...

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Detalhes bibliográficos
Main Authors: Peñalosa-Ruiz, Georgina, Aranda, Cristina, Ongay-Larios, Laura, Colon, Maritrini, Quezada, Hector, Gonzalez, Alicia
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3458083/
https://ncbi.nlm.nih.gov/pubmed/23049841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0045702
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