Saccharomyces cerevisiae Differential Functionalization of Presumed ScALT1 and ScALT2 Alanine Transaminases Has Been Driven by Diversification of Pyridoxal Phosphate Interactions

Saccharomyces cerevisiae arose from an interspecies hybridization (allopolyploidiza-tion), followed by Whole Genome Duplication. Diversification analysis of ScAlt1/ScAlt2 indicated that while ScAlt1 is an alanine transaminase, ScAlt2 lost this activity, constituting an example in which one of the me...

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Main Authors: Erendira Rojas-Ortega, Beatriz Aguirre-López, Horacio Reyes-Vivas, Martín González-Andrade, Jose C. Campero-Basaldúa, Juan P. Pardo, Alicia González
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Microbiology
Assuntos:
paralogous genes
pyridoxal phosphate binding
alanine transaminases
functional diversification
structural organization
alanine metabolism
Acceso en liña:http://journal.frontiersin.org/article/10.3389/fmicb.2018.00944/full
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